CC No

IND-057-[SE]

Title

Tuberculosis Research and Training

Head of Institution

Dr P.R. Narayanan

PI Name

Dr P.R. Narayanan

PI Designation

Director 

Institute Name

Tuberculosis Research Centre, Chennai

Address

Indian Council of Medical Research

Phone

(044) 28369500/28369600 

Mayor V.R. Ramanathan Road, Old Spur Tank Road, Chetput 

Fax

91-044-28362528/28362525 

Chennai.600031 

E-Mail

nrparanj@md2.vsnl.net.in 

India 

HQ Unit

STB

SEARO File

T9/72/1 

SEARO Department

CDS

Technical Unit

STB

Area Code

TB

Area

Tuberculosis

Functions of the Centre

Status Details

Initial Designation Date

16-Sep-1985 

Redesignation due on

13-Jun-2009 

Last Designation Date

14-Jun-2005 

Current Status

Redesignated 

Status Comments

The insititute has been redesignated vide RD's letter no. T9/72/1 dated 14 June 2005 

Introduction

Origin of the proposal, technical programme which is sponsoring, reasons for proposed designation

Redesignation upon successful previous tenure. 

Steps that have led to this proposal, eg site-visits by WHO staff, previous participation of the institution, joint development of a workplan, etc.

Visit by Dr Tom Frieden and other research work carried out by WHO through the institution. 

Comments & Composition of the Institute

The Tuberculosis Research Centre (TRC), formerly known as Tuberculosis Chemotherapy Centre is a permanent research institute of the Indian Council of Medical Research (ICMR), an autonomous organization under the Ministry of Health and Family Welfare, Government of India. It was established in 1955, jointly by the ICMR, World Health Organization, Government of Tamil Nadu, and USPHS to determine the feasibility, efficacy and safety of domiciliary chemotherapy for sputum positive pulmonary tuberculosis patients. 

Statutory functions of the institution ; formal links with other institutions

See the attached institutional profile. 

Administrative Structure

Administrative and Scientific Responsibility

Dr P.R. Narayanan 

National and International Advisory Boards ; Composition & Terms of Reference

See attached institutional profile. 

List of Senior Staff

See attached institutional profile. 

Facilities Available (labs, training facilities, documentation centre, etc.)

See attached institutional profile. 

Workplan

Terms of Reference

1. To conduct studies on the efficacy and feasibility of TB case management including for MDR-TB and HIV related TB in order to determine the effectiveness of current recommendations for diagnostic and treatment policies of national TB control programmes; and to determine the efficacy of treatment of latent TB infection in HIV-TB;

2. to conduct operational and basic research, aimed at providing the evidence base for best practices, measuring the epidemiological impact of the control strategies and developing new diagnostic tools; the research agenda should be determined by the needs for improving the TB programme, as part of overarching health systems development;

3. to develop and test training materials/modules addressing training needs for national TB programmes, including TB-HIV and laboratory.

4. to avail the most appropriate laboratory services, as part of the Institute's role as a national and supranational mycobacteriology reference laboratory, to support building laboratory capacity in Member countries, including monitoring of drug resistance, undertaking identification tests for classifying mycobacteria, and providing technical support to Member countries, when requested.

List Of Activities

Activity ID

Activity Title

Year1

Year2

Year3

Year4

1

To conduct studies on HIV-related tuberculosis in order to determine the effectiveness of current recommendations for diagnostic and treatment policies.

Yes

Yes

Yes

Yes

10

To carry out monitoring of drug-resistance in tuberculosis patients in India and other countries in the South-East Asia Region;

Yes

Yes

Yes

Yes

11

To undertake identification tests for classification and typing of mycobacteria;

Yes

Yes

Yes

Yes

12

To carry out research on standardization and simplification of laboratory procedures for diagnosis of tuberculosis, including the development of immunodiagnostic tests;

Yes

Yes

Yes

Yes

13

To provide supervision of the work of bacteriology laboratories undertaking tuberculosis bacteriology; and

Yes

Yes

Yes

Yes

14

To provide training to laboratory personnel for undertaking standardized laboratory procedures for bacteriological and immunodiagnostic tests for tuberculosis.

Yes

Yes

Yes

Yes

2

To conduct clinical trials and feasibility studies on preventive treatment of latent tuberculosis infection in HIV-infected persons.

Yes

Yes

Yes

Yes

3

To conduct training of trainers and develop training materials to improve management of HIV related tuberculosis

No

Yes

Yes

Yes

4

To carry out operational research to strengthen and integrate HIV and TB control programmes.

No

Yes

Yes

Yes

5

To develop and test management strategies for patients with MDRTB

No

Yes

Yes

Yes

6

To carry out controlled clinical trials for the treatment of pulmonary and extra-pulmonary tuberculosis.

Yes

Yes

Yes

Yes

7

To carry out epidemiological studies in the field of tuberculosis in general and evaluate the epidemiological impact of DOTS in particular.

Yes

Yes

Yes

Yes

8

To carry out operational and basic research for better control of tuberculosis

Yes

Yes

Yes

Yes

9

To conduct training of trainers and develop training materials to improve DOTS implementation

Yes

Yes

Yes

Yes